SIMBA Collected Datasets
The SIMBA Capsule collects uncontaminated luminal fluid from the small intestine that is preserved at the site of collection. Our clinical validation data sets demonstrate the significant differences from stool samples and the comparison with endoscopy aspirates collected from the duodenum.
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Metabolomic heatmap demonstrating stark differences in the metabolites of samples obtained from the SIMBA capsule as compared to fecal, and strong similarities compared to endoscopy. Samples are arranged horizontally.
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PCoA plot demonstrating the degree of similarity between the 16s sequenced bacterial profiles, genus level.
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Stark differences in Short Chain Fatty Acids from different regions of the GI : Endoscopic aspirate from Duodenum; Capsule aspirate from the Jejenum/Ileum and Stool
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Stark differences in Bile Acids from different regions of the GI : Endoscopic aspirate from Duodenum; Capsule aspirate from the Jejenum/Ileum and Stool
Capsules ingested with probiotic strains demonstrate the ability of the SIMBA capsule to capture in real-time the arrival of the specific strains to the small intestine.l
Aspirate collected from the small intestine via the SIMBA capsule is anaerobically preserved and sealed at the collection site, enabling the isolation of novel strains.
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